Magnetic-Fe/Fe₃O₄-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

• Hongwang Wang,
• Tej B. Shrestha,
• Matthew T. Basel,
• Raj K. Dani,
• Gwi-Moon Seo,
• Sivasai Balivada,
• Marla M. Pyle,
• Heidy Prock,
• Olga B. Koper,
• Prem S. Thapa,
• David Moore,
• Ping Li,
• Viktor Chikan,
• Deryl L. Troyer and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2012, 3, 444–455, doi:10.3762/bjnano.3.51

• and by activating the immune system. Keywords: cell-based delivery; chemotherapeutic prodrug; magnetic Fe/Fe3O4 nanoparticles; SN38; Introduction Irinotecan (CPT-11) is a potent chemotherapeutic prodrug against various types of cancer, such as colorectal, lung, and ovarian cancer [1][2][3][4][5]. It

• physiological conditions, which is highly desired for a cell-based delivery system. We have established that when Mo/Ma cells are used as carriers, the tumor-homing process takes about one day. Their robust stability will ensure the integrity of the MNPs after delivery to the tumor site. The uptake efficiency